SENP6 Antilichaam - C-terminal regio : HRP (ARP50600 P050-HRP)

SUMO1/sentrin specific peptidase 6

SSP1, SUSP1

26054

Q9GZR1

NP_001093879

Human, Cow, Horse, Pig

The immunogen is a synthetic peptide directed towards the C terminal region of human SENP6

SENP6 is a UBL-specific protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. It does not seem to be involved in the processing of full-length SUMO proteins to their mature forms. SENP6 deconjugates SUMO1 from RXRA, leading to transcriptional activation. It may act preferentially on substrates containing 3 or more SUMO2 or SUMO3 moieties.Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]) .[supplied by OMIM].

UBC; SP1; LMNA; COPS5; SUMO2; KAT5; SUMO1; PLA2G2A; RUVBL2; ARNT

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

SENP6 is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 79%; Horse: 79%; Human: 100%; Pig: 91%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

125kDa

Olsen, J.V., (2006) Cell 127 (3), 635-648

Wet Ice

1105

SENP6

SENP6

Rabbit

Sentrin-specific protease 6

NM_001100409

MNLANWFPPPRMRTKREEIRNIILKLQEDQSKEKRKHKDTYSTEAPLGEG