SEPT5 Antilichaam

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

5413

Q99719

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human SEPT5 (NP_002679.2) .

Unconjugated

Primary Antibodies

Cell Cycle, Chemokines & Cytokines, Immunology, Neuroscience, Signal Transduction

Affinity purification

Jurkat

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 43kDa

IgG

SEPT5.

NIH/3T3

Mouse brain

Mouse heart

Mouse kidney

Rat brain

Septin 5

Homo sapiens

SEPT5, CDCREL-1, CDCREL1, H5, HCDCREL-1, Peanut-like 1 (Drosophila), Peanut-like 1, Peanut-like protein 1, Septin 5, Septin-5, CDCREL, PNUTL1

WB, IHC

Liquid