SERPINB8 Antilichaam - middengebied: Biotine (ARP57800_P050-Biotin)

Serpin peptidase inhibitor, clade B (ovalbumin), member 8

PI8, CAP2, PI-8, PSS5, C18orf53

5271

P50452

NP_942130

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the middle region of human SERPINB8

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]) . A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]) .

SUMO2; LARS; UBC; CAP1; PRSS1; F10; F2; FURIN; BCL2

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 91%; Dog: 92%; Guinea Pig: 83%; Horse: 92%; Human: 100%; Mouse: 100%; Pig: 92%; Rabbit: 86%; Rat: 100%; Sheep: 91%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

43kDa

Wet Ice

374

SERPINB8

SERPINB8

Rabbit

Serpin B8

NM_198833

KAWTNSEKLTKSKVQVFLPRLKLEESYDLEPFLRRLGMIDAFDEAKADFS