SESTRIN2 Antilichaam

SESTRIN2, also known as Hi95, is a member of the sestrin family of PA26-related proteins and is induced following DNA damage or oxidative stress (1) . SESTRIN2 and the related protein SESTRIN1 interact with the NRF2 suppressor KEAP1, the autophagy substrate p62 and the ubiquitin ligase RBX1 to protect cells against oxidative stress by activating NRF2 and promoting the p62-dependent autophagic degradation of KEAP1 (2) . SESTRIN2 also negatively regulates TOR signaling by activating AMP-activated protein kinase (AMPK) and TSC2 phosphorylation (3), thereby protecting cells against energetic stress-induced death (4) .

83667

P58004

NP_113647

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Autophagy, Homeostasis

SESTRIN2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 - Mouse Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (77%)

SESTRIN2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SESTRIN2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SESTRIN2 antibody is human, mouse and rat reactive. At least two isoforms of SESTRIN2 are known to exist; this antibody will detect both isoforms. SESTRIN2 antibody is predicted to not cross-react with SESTRIN1.

SESN2

Cat. No. 1305 - Human Kidney Tissue Lysate

Sestrin 2

Homo sapiens

Budanov AV, Shoshani T, Faerman A, et al. Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability. Oncogene 2002; 21:6017-31.

Bae SH, Sung SH, Oh SY, et al. Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage. Cell Metab. 2013; 17:73-84.

Budanov AV and Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Mol. Cell 2008; 134:451-60.

Ben-Sahra I, Dirat B, Laurent K, et al. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death. Cell Death and Diff. 2013; 20:611-9.

SESTRIN-2, SES2, SEST2, SESN2, HI95

ELISA, WB, IHC-P, IF

13899299

Liquid