SETD7/SET7/9 Monoklonale antilichamen

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP50-mediated transcriptional activation.

SETD7

Q8WTS6

Human

Recombinant Human SETD7 / SET7 / 9 protein

KMT; SETD; KIAA; SET; SETD7; KMT7; SET7; SET7/9; SET9; KIAA1717

12F11

Unconjugated

WB

Epigenetics and Nuclear Signaling

Protein A

1 mg/mL

WB 1:500-1:1000

0.2 μm filtered solution in PBS

Ice bag

This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free. Avoid repeated freeze-thaw cycles.

https://789.bio/eb/ECXlnrtx

41 kDa

53 kDa

IgG1