SF3A1 Antilichaam - N-terminaal gebied: Biotine (ARP40615 P050-Biotin)

Splicing factor 3a, subunit 1, 120kDa

PRP21, PRPF21, SAP114, SF3A120

10291

Q15459

NP_005868

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human SF3A1

SF3A1 is the subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs.This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms.

HDAC1; FUS; HUWE1; UBC; RPA3; RPA2; RPA1; WWOX; ZBTB1; SUZ12; EED; RNF2; rev; NR3C1; APBB1; HNRNPR; GAS7; CCDC6; PPP4R2; BRCC3; SMEK1; PRPF40A; GAPVD1; WBP4; TCERG1; HDAC11; HDAC6; SF3A3; DDX42; RBM10; SF3A2; SF1; WHSC1; IL7R; CSNK2A1; WDR77; RBFOX2; SMUR

Biotin

Polyclonal Antibody

IF, IHC, WB

Affinity Purified

SF3A1 is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

89kDa

Ewing, R.M., Mol. Syst. Biol. 3, 89 (2007)

Wet Ice

793

SF3A1

SF3A1

Rabbit

Splicing factor 3A subunit 1

NM_005877

QQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLT

1