SFRS1 Antilichaam - middengebied: Biotine (ARP40692 T100-Biotine)

Serine/arginine-rich splicing factor 1

ASF, SF2, SFRS1, SF2p33, SRp30a

6426

Q07955

NP_008855

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human SFRS1

SFRS1 is a member of the arginine/serine-rich splicing factor protein family, and functions in both constitutive and alternative pre-mRNA splicing. The protein binds to pre-mRNA transcripts and components of the spliceosome, and can either activate or repress splicing depending on the location of the pre-mRNA binding site. The protein's ability to activate splicing is regulated by phosphorylation and interactions with other splicing factor associated proteins. Multiple transcript variants encoding different isoforms have been found for this gene.Alternative mRNA splicing plays an important role in development and differentiation; many transcripts are spliced differently in distinct cell types and tissues. Both constitutive and alternative splicing occurs on spliceosomes, which are complex particles composed of small nuclear ribonucleoproteins (snRNPs) and non-snRNP proteins. The SR family of non-snRNP splicing factors is characterized by the presence of an RNA recognition motif and a serine- and arginine-rich (SR) domain. SR proteins are required at early stages of spliceosome assembly, have distinct but overlapping specificities for different pre-mRNAs, and can alter splice site choice, suggesting that they may be involved in the regulation of alternative splicing in vivo. Two of the SR proteins, ASF/SF2 (SFRS1) and SC35 (SFRS2; MIM 600813), have been extensively characterized (Bermingham et al., 1995) .[supplied by OMIM].

TRAF3IP2; HUWE1; SPRTN; STAU1; UBC; MDM2; ZBTB1; RNF2; EZH2; EED; SUZ12; PARK2; SRPK2; SRPK1; SRPK3; FBXO6; YWHAE; U2AF2; PAN2; MPG; CIR1; FN1; CDK6; HNRNPA0; RNPS1; SRSF10; NXF1; PRPF4; BCL10; U2AF1; SRSF4; MAGOH; SMURF1; EIF4A3; ESR1; ECT2; BRCA1; BARD1

Biotin

Polyclonal Antibody

WB

There is BioGPS gene expression data showing that SRSF1 is expressed in HepG2

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

27kDa

Li, S.H., (2005) J. Biol. Chem. 280 (50), 41761-41768

Wet Ice

248

SRSF1

SRSF1

Rabbit

Serine/arginine-rich splicing factor 1

NM_006924

GVVEFVRKEDMTYAVRKLDNTKFRSHEGETAYIRVKVDGPRSPSYGRSRS