SGI-1027
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Potent and selective inhibitor of DNA methyl transferase inhibiting DNMT1, DNMT3A and DNMT3B with comparable potency (IC50=12.5, 8.0 and 7.5 M respectively) .1 Treatment of various cancer cell lines with SGI-1027 results in selective degradation of DNMT1 (MG-132 sensitive) with minimal effect on DNMT3A and 3B at 2.5-5 M.1 Prolonged treatment of RKO cells resulted in reexpression of silenced tumor suppressor genes.1 Synergizes with doxorubicin at growth inhibition in neuroblastoma cell lines.2 Disrupts the MKK3-MYC complex in cells and inhibits MYC transcriptional activity in colon and breast cancer cells.3
Unconjugated
Off-white solid
-20°C
Beschrijving
SGI-1027 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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