SGK1 Antilichaam

SGK1 Antibody: Serum and glucocorticoid-regulated protein kinase 1 (SGK1) is a member of the AGC family of serine/threonine kinases that plays an important role in cellular stress response and cell survival. SGK1 is transcriptionally activated by numerous stimuli, including serum, glucocorticoids, osmotic stress, and hormones. SGK1 functions as a regulator of cell survival and ion channels and transporters such as ENaC or KCNA3/Kv1.3. It phosphorylates and negatively regulates pro-apoptotic FOXO3A. SGK1 is thought to play an essential function in nephropathy and cardiovascular development.

6446

O00141

NP_005618

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

SGK1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1319 - Human Stomach Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (89%), Chicken: (84%), Rabbit: (89%)

SGK1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SGK1 antibody can be stored at 4 ˚ C for 3 months and -20 ˚ C stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SGK1 antibody is predicted to not cross-react with other SGK protein family members. At least five isoforms are known to exist

SGK1

Cat. No. 10-801 - Human Stomach Tissue Slide

Serum/glucocorticoid regulated kinase 1

Homo sapiens

Webster MK, Goya L, Ge Y, et al. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum. Mol. Cell Biol. 1993; 13:2031-40.

Leong ML, Maiyar AC, Kim B, et al. Expression of the serum- and glucocorticoid-inducible protein kinase, Sgk, is a cell survival response to multiple types of environmental stress stimuli in mammary epithelial cells. J. Biol. Chem. 2003; 278:5871-82.

Firestone GL, Giampaolo JR, O'Keeffe BA, et al. Stimulus-dependent regulation of serum and glucocorticoid inducible protein kinase (SGK) transcription, subcellular localization and enzymatic activity. Cell. Physiol. Biochem. 2003; 13:1-12.

Brunet A, Park J, Tran H, et al. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a) . Mol. Cell Biol. 2001; 21:952-65.

SGK1 Antibody: SGK, SGK

ELISA, WB, IHC-P, IF

25168263

Liquid