SGSM1 Antilichaam

SGSM1 Antibody: Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM1 (RUTBC2) is a 1,148 amino acid protein that localizes to the Golgi apparatus and is mainly expressed in the CNS. SGSM1 interacts with RAP and RAB subfamily members of the small G proteins, and function as modulators of RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways.

129049

Q2NKQ1

NP_001035037

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Neuroscience

SGSM1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1362 - Human Cerebellum Tissue Lysate

1 mg/mL

SGSM1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SGSM1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

126 kDa

IgG

At least four isoforms of SGSM1 are known to exist; SGSM1 antibody will detect all four isoforms.

SGSM1

Cat. No. 10-301 - Human Brain Tissue Slide

Small G protein signaling modulator 1

Homo sapiens

Bar-Sagi D and Hall A. Ras and Rho GTPases: a family reunion. Cell 2000; 103:227-38.

Colicelli J. Human ras superfamily proteins and related GTPases. Sci. STKE 2004; 250:RE13.

Yang H, Sasaki T, Minoshima S, et al. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB) -mediated signaling pathway. Genomics 2007; 90:249-60.

Williams JA, Chen X and Sabbatini ME. Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am. J. Physiol. Endocrinol. Metab. 2009; 296:E405-14.

SGSM1 Antibody: RUTBC2, KIAA1941, RUTBC2, Small G protein signaling modulator 1, RUN and TBC1 domain-containing protein 2

ELISA, WB, IF

90577167

Liquid