SHC1 Antilichaam - C-terminaal gebied: Biotine (ARP50490_P050-Biotine)

SHC (Src homology 2 domain containing) transforming protein 1

SHC, SHCA

6464

P29353

NP_003020

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human SHC1

SHC1 is a signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span.

GRB2; Socs5; IGF1R; UBC; EGFR; Hgf; GAB2; GAB1; CBL; ERBB4; ERBB3; ERBB2; NEDD8; ZAP70; DOK1; KRT77; TUBB2B; TUBB; EEF1A1P5; ARAP1; TIMM50; UBASH3B; TUBA1C; PPP1R9B; TUBB6; ATAD3B; TUBA4B; TUBAL3; MYH14; LRRK1; TUBA8; RAB3GAP2; CORO1C; RUVBL2; CCT2; HAX1

Biotin

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

52kDa

George, R., (2008) J. Mol. Biol. 377 (3), 740-747

Wet Ice

474

SHC1

SHC1

Rabbit

SHC-transforming protein 1

NM_003029

AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ