SHOC2-RAS PPI-IN-1

SHOC2-RAS PPI-IN-1 (compound 6) is a non-covalent competitive inhibitor targeting the interaction between SHOC2 and RAS proteins. SHOC2-RAS PPI-IN-1 has an IC50 of 0.048 μM and a KD of 0.065 μM for NRASQ61R. SHOC2-RAS PPI-IN-1 can inhibit the activity of the SMP phosphatase complex, leading to increased CRAFS259 phosphorylation levels, thereby blocking the MAPK signaling pathway (such as reducing the levels of pMEK and pERK), inducing tumor cell cycle arrest and apoptosis. SHOC2-RAS PPI-IN-1 can be used for targeted research on malignant tumors such as melanoma and colorectal cancer with NRASQ61R mutations[1].

12352005

H302, H315, H319, H335

Apoptosis; Ras

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway

Cancer-Kinase/protease

Cancer

99.50

DMSO : 100 mg/mL (ultrasonic)

O=C(O)C(C)(C)[C@H](NC(CC1=CC=CC(I)=C1)=O)C2=CC=C(OC(N3)=O)C3=C2

C20H19IN2O5

494.28

H302, H315, H319, H335

[1]Hauseman ZJ, et al. Targeting the SHOC2-RAS interaction in RAS-mutant cancers. Nature. 2025 Jun;642 (8066) :232-241.

Room Temperature

-20°C, 3 years; 4°C, 2 years (Powder)

http://file.medchemexpress.com/batch_PDF/HY-202699/SHOC2-RAS-PPI-IN-1-SDS-MedChemExpress.pdf

Reference compound1

No Development Reported