SIGIRR Antilichaam - C-terminalgebied: Biotine (ARP49664_P050-Biotine)

Single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

TIR8, IL-1R8

59307

Q6IA17

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

The immunogen is a synthetic peptide directed towards the C terminal region of human SIGIRR

SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. It attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through a TIR-TIR domain interaction with TLR4. Through its extracellular domain it interferes with the heterodimerization of Il1R1 and IL1RAP.

APP; UBC; SIGIRR; TLR9; TLR5; TLR4; TRAF6; IRAK1; RPN1; IL1R1; ENO2

Biotin

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

25kDa

Wet Ice

224

SIGIRR

SIGIRR

Rabbit

PVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM