SIGLEC15 Peptide

SIGLEC15 Antibody: Siglecs are vertebrate cell-surface lectins that recognize sialylated glycans and are involved in many physiological processes, such as glycoprotein turnover, cellular trafficking, and pathogen recognition. Most Siglecs are expressed on cells of the immune system. SIGLEC15 is a type-I transmembrane protein consisting of two immunoglobulin (Ig) -like domains, a transmembrane domain containing a lysine residue, and a short cytoplasmic tail. SIGLEC15 can interact with the activating adaptor molecules DAP12/10. Its activating signaling potential and unique preference for glycan recognition implies that SIGLEC15 may be involved in the immune surveillance of tumors and probably plays a conserved, regulatory role in the immune system of vertebrates.

284266

Q6ZMC9

NP_998767

Peptides

200 ug/mL

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Blue Ice

Store SIGLEC15 Peptide at -20˚ C, stable for one year.

SIGLEC15 Peptide is used for blocking the activity of the SIGLEC15 Antibody

Sialic acid binding Ig-like lectin 15

Homo sapiens

Crocker and Redelinghuys. Biochem. Soc. Trans. 2008; 36:1467-71.

Angata et al. Glycobiology 2007; 17:838-46.

Hiruma et al. Biochem. Biophys. Res. Commun. 2011; 409:424-9.

SIGLEC15 Antibody: CD33L3, HsT1361, SIGLEC-15, CD33L3, Sialic acid-binding Ig-like lectin 15, CD33 antigen-like 3, Siglec-15

Blocking

Human

47106069

Liquid