SIGLEC7 Antilichaam - middengebied HRP (ARP47018 P050-HRP)

Sialic acid binding Ig-like lectin 7

P75, QA79, AIRM1, CD328, AIRM-1, CDw328, D-siglec, SIGLEC-7, SIGLECP2, SIGLEC19P, p75/AIRM1

27036

Q9Y286

NP_055200

Human, Cow, Dog, Guinea Pig, Horse

The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC7

SIGLEC7 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. In the immune response, it may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC7 mediates inhibition of natural killer cells cytotoxicity. It may also play a role in hemopoiesis. SIGLEC7 inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro) .

SOCS3; TRAF4; PTPN11; GRB2

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

SIGLEC7 is strongly supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 85%; Dog: 100%; Guinea Pig: 86%; Horse: 92%; Human: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

51kDa

Jaroenpool, J., Cell. Immunol. 250 (1-2), 91-104 (2007)

Wet Ice

467

SIGLEC7

SIGLEC7

Rabbit

Sialic acid-binding Ig-like lectin 7

NM_014385

WRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLNLSLQQ