Signaaltransducer en activator van transcriptie 2 Adenovirus (Ad-STAT2)

Stats (signal transducers and activators of transcription) are tyrosine phosphorylated transcription factors activated by JAK family kinases. Various ligands, including interferons and growth factors, induce activation of the JAK kinases, which induce Stat activation. Stat1 and Stat2 are induced by IFN-α and form a heterodimer that is part of the ISGF-3 transcription factor complex. Stat3Î2 is activated by EGF and IL-6. Stat3α is activated by EGF. Highest expression of Stat4 is observed in the testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 can be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways. Stat-1 and Stat-3 bind the serum-inducible element (SIE) and GAS/ISRE elements are also known to be STAT-binding sites.

Signal transducer and activator of transcription 2 Adenovirus

41106621

3822190000

Pre-Made

Dry Ice

-80C

12 Months

Ad-STAT2

Human Adenovirus Type5 (dE1/E3)

CMV (ubiquitous)

DMEM, 2% BSA, 2.5% Glycerol

1x10^10 PFU/ml