SIK1 Antilichaam

SIK1 Antibody: Salt-inducible kinase 1 (SIK1), also known as SNF1LK or MSK, plays a role in histone modification and G2/M cell cycle regulation. It is a 783 amino acid protein that contains one UBA domain and belongs to the Ser/Thr protein kinase family (AMPK subfamily) . Localized to both the nucleus and the cytoplasm, SIK1 is a class II HDAC kinase that uses magnesium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins and is thought to be important for the early stages of skeletal muscle growth and myocardial cell differentiation.

150094

P57059

NP_775490

Human

Unconjugated

Primary Antibodies

Signal Transduction

SIK1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1308 - Human Small Intestine Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (73%), Mouse: (73%)

SIK1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SIK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Two isoforms of SIK1 are known to exist; this antibody will detect both isoforms. SIK1 antibody is predicted to not cross-react with other SIK protein family members.

SIK1

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Salt-inducible kinase 1

Homo sapiens

Stephenson A, Huang GY, Nguyen NT, et al. SNF1LK encodes a protein kinase that may function in cell cycle regulation. Genomics 2004; 83:1105-15

Ruiz JC, Conlon FL, and Robertson EJ. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech. Dev. 1994; 48:153-64

Lizcano JM, Goransson O, Toth R, et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 2004; 23:833-43.

Sjö strö m M, Senstrom K, Eneling K, et al. SIK1 is part of a cell sodium-sensing network that regulates active sodium transport through a calcium-dependent process. Proc. Natl. Acad. Sci. USA 2007; 104:16922-7.

SIK1 Antibody: MSK, SIK, SNF1LK, Salt-inducible kinase 1, SIK-1

ELISA, WB, IHC-P

116256471

Liquid