SIK3 Antilichaam

SIK3 Antibody: Salt-inducible kinase family (SIKs) proteins are thought to have a role in steroidogenesis, adipogenesis or regulation of tumor malignancy. Three members (SIK1, SIK2 and SIK3) in the SIK family have been identified thus far. Their kinase domain sequences are closely homologous to those of AMP-activated protein kinase (AMPK) . SIK3 can be phosphorylated by a tumor-suppressor kinase LKB1. It is highly and preferentially expressed in ovarian tumors but not in adenomyosis and leiomyoma and may be a potential diagnostic marker for ovarian cancers.

23387

Q9Y2K2

NP_079440

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

SIK3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

SIK3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SIK3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgY

At least three isoforms of SIK3 are known to exist; this antibody will detect two isoforms. SIK3 antibody is predicted to not cross-react with SIK1 and SIK2.

SIK3

SIK family kinase 3

Homo sapiens

Katoh Y, Takemori H, Horike N, et al. Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis. Mol. Cell. Endocrinol. 2004; 217:109-12.

Al-Hakim AK, Gö ransson O, Deak M, et al. 14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK. J. Cell Sci. 2005; 118:5661-73.

Charoenfuprasert S, Yang YY, Lee YC, et al. Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer. Oncogene 2011; 30:3570-84.

SIK3 Antibody: L19, QSK, SIK-3, KIAA0999, L19, Salt-inducible kinase 3

ELISA, WB, IF

38569491

Liquid