Silodosine carbonzuur onzuiverheid

Silodosin carboxylic acid impurity (KMD-3293) is an inactive silodosin metabolite. Silodosin carboxylic acid impurity is the major metabolite that can be generated via oxidation by alcohol and aldehyde dehydrogenase. Silodosin carboxylic acid impurity can be studied in research for benign prostatic hyperplasia[1][2].

1357252-79-9

KMD-3293

12352005

H302-H315-H319-H335

Endogenous Metabolite

Metabolic Enzyme/Protease

Metabolic Disease

OC(CCN1C2=C(C(N)=O)C=C(C[C@@H](C)NCCOC3=C(C=CC=C3)OCC(F)(F)F)C=C2CC1)=O

C25H30F3N3O5

509.52

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

[1]Shah, P. A., & Shrivastav, P. S. (2018) . Novel LC-MS/MS method for the quantification of silodosin and its metabolites in human plasma. Bioanalysis, 10 (1), 7–10.|[2]Lepor, H., & Hill, L. A. (2010) . Silodosin for the treatment of benign prostatic hyperplasia: pharmacology and cardiovascular tolerability. Pharmacotherapy, 30 (12), 1303–1312.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-Z12431/

Reference compound1

No Development Reported