Sin Nombre Virus Glycoproteïne 2 Antilichaam

Sin Nombre virus (SNV) is a rodent-borne hantavirus of the family Bunyaviridae, an enveloped, negative-sense RNA viruses with a tripartite genome that can cause hantavirus pulmonary syndrome (HPS) (1) . Hantavirus glycoprotein precursor (GPC) is posttranslationally cleaved into two glycoproteins G1 (Gn) and G2 (Gc) . While the G1 glycoprotein is is thought to be degraded by the host autophagy machinery, and this autophagic clearance is required for efficient virus repliaction (2), no such degradation was observed for the G2 glycoprotein.

2654026

Q89905

NP_941974

Virus

Unconjugated

Primary Antibodies

Infectious Disease

Sin Nombre virus glycoprotein 2 antibody is affinity chromatography purified via peptide column.

1 mg/mL

Sin Nombre virus glycoprotein 2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Sin Nombre Glycoprotein 2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Sin Nombre virus glycoprotein 2 antibody can detect 10ng Sin Nombre virus glycoprotein 2 peptide in ELISA at 1 μ g/ml.

SNVsMgp1

SNVsMgp1 glycoprotein precursor

Sin Nombre virus

Spiropoulou CF, Morzunov S, Feldmann H, et al. Genome structure and variability of a virus causing hantavirus pulmonary syndrome. Virology 1994; 200:715-23.

Hussein ITM, Cheng E, Ganaie SS, et al. Autophagic clearance of Sin Nombre hanatavirus glycoprotein Gn promotes virus replication in cells. J. Virol. 2012; 86:7520-9.

Sin Nombre Virus Glycoprotein 2 Antibody:

ELISA

38371724

Liquid