Sintilimab (Anti-PD-1)

Sintilimab (Anti-PD-1) (IBI308 (Anti-PD-1) ) is a safe and effectivel humanized IgG4 monoclonal antibody that binds to PD-1 with a KD value of 74 pM. Sintilimab (Anti-PD-1) blocks the interaction of PD-1 with its ligands (PD-L1 and PL-L2), consequently helping to restore the endogenous antitumour T-cell response. Sintilimab (Anti-PD-1) combined with prebiotics inhibits tumor volume and regulates immune cell subpopulation balance in lung adenocarcinoma mice. Sintilimab (Anti-PD-1) can be used for the research of classical Hodgkin's lymphoma, non-small cell lung cancer and oesophageal cancer[1][2][3][4][5].

IBI308 (Anti-PD-1)

12352203

PD-1/PD-L1

Immunology/Inflammation

COVID-19-immunoregulation

Cancer; Inflammation/Immunology

[Sintilimab(Anti-PD-1)]

[1]Sheridan M Hoy. Sintilimab: First Global Approval Drugs. 2019 Feb;79 (3) :341-346.|[2]Wang J, et al Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. MAbs. 2019 Nov-Dec;11 (8) :1443-1451.|[3]Zhang L, et al. Sintilimab: A Promising Anti-Tumor PD-1 Antibody. Front Oncol. 2020 Nov 26;10:594558.|[4]Yan Q, et al. Prebiotics Modulate Gut Microbiota-mediated T-cell Immunity to Enhance the Inhibitory Effect of Sintilimab in Lewis Lung Adenocarcinoma Model Mice. Anticancer Agents Med Chem. 2023;23 (17) :1966-1973.|[5]Zhang L, et al. Sintilimab for the treatment of non-small cell lung cancer. Biomark Res. 2022 Apr 18;10 (1) :23.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P99048A/

Inhibitory Antibodies

Phase 4