SIPA1L2 Antilichaam

SIPA1L2 Antibody: Signal-induced proliferation associated-like protein 2 (SIPA1L2) is a member of the SIPA1 family of RapGAPs. Little is known of the role of the SIPA1L2 protein, but recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is likely that SIPA1L2 plays a role in embryo development and cell proliferation, possibly including oncogenesis.

57568

Q9P2F8

NP_065859

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer

SIPA1L2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

SIPA1L2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SIPA1L2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SIPA1L2

Cat. No. 10-301 - Human Brain Tissue Slide

Signal-induced proliferation-associated 1 like 2

Homo sapiens

Minato N and Hattori M. SPA-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis. Cancer Sci.2009; 100:17-23.

Ishida D, Kometani K, Yang H, et al. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell2003; 4:55-65.

Park YG, Zhao X, Lesueur F, et al. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus, Mtes. Nat. Genet.2005; 37:1055-62.

Tsai I-C, Amack JD, Gao Z-H, et al. A Wnt-CKI e-Rap1 pathway regulates gastrulation by modulating SIPA1L2, a Rap GTPase activating protein. Dev. Cell2007; 12:335-47.

SIPA1L2 Antibody: SPAL2, KIAA1389, Signal-induced proliferation-associated 1-like protein 2, SIPA1-like protein 2

ELISA, WB, IHC-P, IF

112421013

Liquid