SIRP alpha Antilichaam

SIRP alpha Antibody: Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.

140885

P78324

NP_542970

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

SIRP alpha Antibody is affinity chromatography purified via peptide column.

Cat. No. 1208 - THP-1 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (88%)

SIRP alpha Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SIRP alpha antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

75 - 110 kDa

IgG

Recognizes SIRP alpha 1, 2 and 3.

SIRPA

Cat. No. 17-008 - THP-1 Cell Slide

Signal-regulatory protein alpha

Homo sapiens

Kharitonenkov A, et al. Nature 1997;386:181-186.

Fujioka Y, et al. Mol Cell Biol 1996;16:6887-6899

Yamao T, et al. Biochem Biophys Res Commun 1997;231:61-67

Brooke GP, et al. Eur J Immunol 1998;28:1-11

SIRP alpha Antibody: BIT, MFR, P84, SIRP, MYD-1, SHPS1, CD172A, PTPNS1, BIT, MYD1, Tyrosine-protein phosphatase non-receptor type substrate 1, Brain Ig-like molecule with tyrosine-based activation motifs, SHP substrate 1

ELISA, WB, ICC

18426911

Liquid