SirT1 (fosfo Ser47) Antilichaam

NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively.

23411

Q96EB6

NP_001135970.1

Human, Mouse

SirT1 (phospho Ser47) antibody was raised against a peptide sequence around phosphorylation site of serine 47 (E-R-S (p) -P-G) derived from Human SirT1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

110 kDa

IgG

The antibody detects endogenous level of SirT1 only when phosphorylated at serine 47.

Western Blot: 1:500~1:1000

SIRT1

Sirtuin 1

Homo sapiens

Gao Z, et al. (2011) J Biol Chem 286, 22227-34. Zschoernig B, Mahlknecht U (2009) Biochem Biophys Res Commun 381, 372-7. Nasrin N, et al. (2009) PLoS One 4, e8414.

HSIR2, hSIRT1, NAD-dependent deacetylase sirtuin 1, SIR1, SIR2L1

WB

7657575

Liquid