SIRT4 Antilichaam

SIRT4 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT4 localizes to mitochondria, inhibits glutamate dehydrogenase, and is thought to be involved in the regulation of insulin secretion.

23409

Q9Y6E7

EAW98182

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

SIRT4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1304 - Human Liver Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

SIRT4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SIRT4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgY

SIRT4

Cat. No. 1404 - Mouse Liver Tissue Lysate

Sirtuin 4

Homo sapiens

Salminen A. SIRT1: regulation of longevity via autophagy. Cell Signal2009; 21:1356-60.

Afshar G and Murnane JP. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae Sir 2. Gene1999; 234:161-8.

Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature2006; 444:868-74.

Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell2001; 107:149-59.

SIRT4 Antibody: SIR2L4, SIR2L4, NAD-dependent protein deacetylase sirtuin-4, NAD-dependent ADP-ribosyltransferase sirtuin-4

ELISA, WB

119618588

Liquid