SIRT5 Antilichaam

SIRT5 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT5 localizes to mitochondria, deacetylates carbamoyl phosphate synthetase 1, and is involved in the regulation of the urea cycle.

23408

Q9NXA8

NP_036373

Human, Mouse

Unconjugated

Primary Antibodies

Homeostasis

SIRT5 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1202 - A431 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%), Bovine: (88%), Chicken: (82%)

SIRT5 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SIRT5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgY

SIRT5

Sirtuin 5

Homo sapiens

Salminen A. SIRT1: regulation of longevity via autophagy. Cell Signal2009; 21:1356-60.

Afshar G and Murnane JP. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae Sir 2. Gene1999; 234:161-8.

Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature2006; 444:868-74.

Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell2001; 107:149-59.

SIRT5 Antibody: SIR2L5, SIR2L5, NAD-dependent protein deacylase sirtuin-5, mitochondrial, Regulatory protein SIR2 homolog 5

ELISA, WB

6912664

Liquid