SJ6986
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SJ6986 is a potent (IC50 = 15 nM for Cereblon; EC50 = 1.5 nM for MV4-11 AML cells), selective, and orally bioavailable molecular glue degrader of the small GTPases G1 to S phase transition 1/2 (GSPT1/2) .1 It displayed selectivity for GPST1/2 over 9000 other proteins including the classic cereblon substrates IKZF1 (Ikaros) and IZKF3 (Aiolos) . SJ6986 displayed efficacy against acute lymphoblastic leukemia cell lines and xenografts.2
Unconjugated
White solid
-20°C
Beschrijving
SJ6986 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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