SKP2 Antilichaam - C-terminalgebied: FITC (ARP30219_P050-FITC)

S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

P45, FBL1, FLB1, FBXL1

6502

Q13309-4

Human, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the C-terminal region of Human SKP2

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19) . In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas.

USP18; CUL1; CDKN1A; SAMHD1; SUGT1; UBC; AR; RND3; CKS1B; MYC; SMAD7; CDKN1B; SKP1; CDK3; CDK2; LATS2; FZR1; CEP192; SF3B3; KMT2A; E2F1; KPNA6; SIRT3; SIRT4; RBX1; CDC14B; NEDD8; SIRT6; KPNA1; HSP90AA1; EP300; CEBPA; CDH1; BRCA1; BARD1; BTRC; SNRPB2; CDC3

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 92%; Guinea Pig: 83%; Horse: 92%; Human: 100%; Pig: 100%; Rabbit: 100%; Rat: 75%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

23kDa

Wet Ice

210

SKP2

SKP2

Rabbit

S-phase kinase-associated protein 2

TLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL