SL010110
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 degradation. SL010110 downregulates the protein level of PEPCK1 without affecting the gene expressions of PEPCK, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. SL010110 significantly improves glucose homeostasis in type 2 diabetic (T2D) mice model. SL010110 can be used for T2D research[1].
380173-90-0
12352005
H315-H319-H335
Histone Acetyltransferase; PEPCK; Sirtuin
Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease
Metabolic Disease
C=CCC1=CC(=C(C=C1)OCC2=CC=C(C(=O)O)O2)OC
C16H16O5
288.30
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
[1]Ren YR, et al. SL010110, a lead compound, inhibits gluconeogenesis via SIRT2-p300-mediated PEPCK1 degradation and improves glucose homeostasis in diabetic mice. Acta Pharmacol Sin. 2021 Nov;42 (11) :1834-1846.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W197205/
Reference compound2
No Development Reported
CBP/p300; SIRT2
Beschrijving
SL010110 is an anti-hyperglycemic agent. SL010110 potently inhibits gluconeogenesis by inhibiting SIRT2, activating p300, and subsequently promoting PEPCK1 degr
Specificaties
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