SLAMF1 Antilichaam

SLAMF1 Antibody: The signaling lymphocyte-activation molecule family member 1 (SLAMF1) is a novel receptor on T cells that potentiates T cell expansion in a CD28-independent manner. SLAMF1 is predominantly expressed by hematopoietic tissues. Reports suggest that the extracellular domain of SLAMF1 is the receptor for the measles virus and acts as a co-activator on both T and B cells. It is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations of the SLAM associated gene may be associated with X-linked lympho-proliferative disease (XLP) .

6504

Q13291

NP_003028

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell

SLAMF1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1472 - Rat Colon Tissue Lysate

1 mg/mL

SLAMF1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SLAMF1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

4 isoforms of SLAMF1 are known to exist; this antibody will is predicted to recognize all 4 isoforms. SLAMF1 antibody is predicted to not cross-react with other SLAM protein family members.

SLAMF1

Signaling lymphocytic activation molecule family member 1

Homo sapiens

Cocks BG, Chang CC, Carballido JM, et al. 1995. A novel receptor involved in T cell activation. Nature 1995; 376:260-3.

Tatsuo H, Ono N, Tanaka K, et al. SLAM (CDw150) is a cellular receptor for measles virus. Nature 2000; 406:893-7.

Aversa G, Chang CC, Carballido JM, et al. Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, Cyclosporin A-sensitive T cell proliferation and IFN-α production. J. Immunol. 1997; 158:4036-44.

SLAMF1 Antibody: SLAM, CD150, CDw150, SLAM, Signaling lymphocytic activation molecule

ELISA, WB, IHC-P, IF

4506969

Liquid