SLAMF4 Antilichaam

SLAMF4 Antibody: The signaling lymphocyte-activation molecule family member 4 (SLAMF4), also known as 2B4, is an important regulator of Natural Killer (NK) cell activation. It is expressed on NK cells as well as on subsets of T cells and interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in this autoimmune disease.

51744

Q9BZW8

NP_1160135

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

SLAMF4 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1224 - Daudi Cell Lysate

1 mg/mL

SLAMF4 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SLAMF4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least three isoforms of SLAMF4 are known to exist. SLAMF4 antibody is predicted to not cross-react with other SLAM protein family members.

CD244

CD244 molecule, natural killer cell receptor 2B4

Homo sapiens

Claus M, Meinke S, Bhat R, et al. Regulation of NK cell activity by 2B4, NTB-A and CRACC. Front. Biosci. 2008; 13:956-65.

Sidorenko SP and Clark EA. The dual-function CD150 receptor sub-family: the viral attraction. Nat. Immunol. 4:19-24.

Assarsson E, Kambayashi T, Persson CM, et al. 2B4/CD48-mediated regulation of lymphocyte activation and function. J. Immunol. 2005; 175:2045-9

Kim JR, Matther SO, Patel RK, et al. Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythmatosus. Clin. Exp. Immunol. 2010; 160:348-58

SLAMF4 Antibody: 2B4, NAIL, Nmrk, NKR2B4, SLAMF4, 2B4, Natural killer cell receptor 2B4, NK cell activation-inducing ligand

ELISA, WB, IF

7706529

Liquid