SLC12A1 Antilichaam

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.

6557

Q13621

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human SLC12A1 (NP_000329.2) .

Unconjugated

Primary Antibodies

Other

Affinity purification

Mouse kidney

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 150kDa

IgG

WB: 1:500 - 1:2000

SLC12A1

Rat kidney

Solute carrier family 12 (sodium/potassium/chloride transporter), member 1

Homo sapiens

SLC12A1, BSC1, MGC48843, NKCC2

WB

Liquid