SLC1A7 Antilichaam

The solute carrier family 1 member 7 (SLC1A7) protein was initially identified as a glutamate transporter coupled to a chloride conductance that is expressed primarily in the retina (1) . More recent evidence indicates that is it widely expressed in peripheral tissues, also (2) . Experiments have shown that SLC1A7 functions as a low-affinity/low-capacity glutamate transport, with an anion channel optimized for anion conductance in the negative voltage range (3) . In the retina, SLC1A7 co-localizes with the serum and glucocorticoid dependent kinase SGK1, and its cell surface expression and activity is regulated SGK1 and its isoform SGK3 (4) .

6512

O00341

NP_001274524

Human, Mouse

Unconjugated

Primary Antibodies

Signal Transduction

SLC1A7 antibody is affinity chromatography purified via peptide column.

Cat. No. 1285 - C2C12 Cell Lysate

1 mg/mL

SLC1A7 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SLC1A7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SLC1A7 antibody is human and mouse reactive. Multiple isoforms of SLC1A7 are known to exist.

SLC1A7

Solute carrier family 1 (glutamate transporter), member 7

Homo sapiens

Arriza JL, Eliasof S, Kavanaugh MP, et al. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. USA 1997; 94:4155-60.

Lee A, Anderson AR, Stevens M, et al. Excitatory amino acid transporter 5 is widely expressed in peripheral tissues. Eur. J. Histochem. 2013; 57:e11.

Schneider N, Cordeiro S, Machtens JP, et al. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. J. Biol. Chem. 2014; 289:1815-24.

Boehmer C, Rajamanickam J, Schniepp R, et al. Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3. Biochem. Biophys. Res. Commun. 2005; 329:738-42.

Solute carrier family 1 (glutamate transporter) member 7, AAAT, excitatory amino acid transporter 5, EAAT5

ELISA, WB, IHC-P, IF

567316146

Liquid