Slc22A17 Antilichaam

Slc22A17 Antibody: The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na (+) /l-carnitine cotransporter (OCTN2) . Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.

51310

Q8WUG5

Q8WUG5

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

Slc22A17 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1220 - SK-N-SH Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (86%)

Slc22A17 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Slc22A17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SLC22A17

Solute carrier family 22, member 17

Homo sapiens

Koepsell H and Endou H. The SLC22 drug transporter family. Pflugers Arch. 2004; 447:666-76.

Rizwan AN and Burckhardt G. Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles. Pharm. Res. 2007; 24:450-70.

Miharada K, Hiroyama T, Sudo K, et. al. Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells. J. Cell Physiol. 2008; 215:526-37.

Devireddy LR, Gazin C, Zhu X, et al. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 2005; 123:1293-305.

Slc22A17 Antibody: BOCT, BOIT, 24p3R, NGALR, hBOIT, NGALR2, NGALR3, BOCT, Solute carrier family 22 member 17, 24p3 receptor

ELISA, WB, IF, IHC-P

27805426

Liquid