SLC29A1 Antilichaam

SLC29A1 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2) . SLC29A1 is a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium (3) . As a nucleoside transporter, SLC29A1 plays an important role in the uptake of nucleoside-based anti-cancer drugs; polymorphisms of point mutations in the gene encoding this protein may affect the efficacy of these drugs (4) .

2030

Q99808

NP_004946

Human

Unconjugated

Primary Antibodies

Cancer, Homeostasis

SLC29A1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1316 - Human Ovary Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (81%), Mouse: (75%)

SLC29A1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SLC29A1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SLC29A1 antibody is human specific. SLC29A1 antibody is predicted to not cross-react with other SLC29 proteins.

SLC29A1

Cat. No. 11-201 - Human Ovary Tissue Slide

Solute carrier family 29 (equilibrative nucleoside transporter), member 1

Homo sapiens

Griffiths M, Beaumont N, Yao SY, et al. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat. Med. 1997; 3:89-93.

Young JD, Yao SY, Baldwin JM, et al. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol. Aspects. Med. 34:529-47.

Mangravite LM, Xiao G, and Giacomini KM. Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells. Am. J. Physiol. Renal Physiol. 284:F902-10.

Zimmerman EI, Huang M, Leisewitz AV, et al. Identification of a novel point mutation in ENT1 that confers resistance to Ara-C in human T cell leukemia CCRF-CEM cells. FEBS Lett. 2009; 583:425-9.

Solute carrier family 29 member 1, Equilibrative nucleoside transporter 1, ENT1

ELISA, WB, IHC-P, IF

4826716

Liquid