SLC29A3 Antilichaam

SLC29A3 is a member of the equilibrative nucleoside transporter family which plays a key role in nucleoside and nucleobase uptake for salvage pathways of nucleotide synthesis (1,2) . SLC29A3 is a transmembrane glycoprotein that localizes to the lysosomal membrane and is a broad selectivity, low affinity nucleoside transporter (3) . Mutations in the SLC29A3 gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism (4) . A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus (5) .

55315

Q9BZD2

NP_060814

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Homeostasis

SLC29A3 antibody is affinity chromatography purified via peptide column.

Cat. No. 1410 - Mouse Bladder Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (95%)

SLC29A3 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SLC29A3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SLC29A3 antibody is human, mouse and rat reactive. At least two isoforms of SLC29A3 are known to exist; this antibody will detect both isoforms. SLC29A3 antibody is predicted to not cross-react with other SLC29 proteins.

SLC29A3

Solute carrier family 29 (equilibrative nucleoside transporter), member 3

Homo sapiens

Hyde RJ, Cass CE, Young JD, et al. The ENT family of eukaryotic nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Mol. Membr. Biol. 2001; 18:53-63.

Young JD, Yao SY, Baldwin JM, et al. The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29. Mol. Aspects. Med. 34:529-47.

Baldwin SA, Yao SY, Hyde RJ, et al. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J. Biol. Chem. 2005; 280:15880-7.

Priya TP, Philip N, Molho-Pessach V, et al. H syndrome: novel and recurrent mutations in SLC29A3. Br. J. Dermatol. 2010; 162:1132-4.

Solute carrier family 29 member 3, Equilibrative nucleoside transporter 3, ENT3, HCLAP, HJCD, PHID

ELISA, WB, IHC-P, IF

148596922

Liquid