SLC30A8 Antilichaam

SLC30A8 Antibody: SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1) . Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3) . SLC30A8 expression in -cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4) .

169026

Q8IWU4

NP_776250

Human

SLC30A8 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human SLC30A8.

Unconjugated

Primary Antibodies

Homeostasis

SLC30A8 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1307 - Human Pancreas Tissue Lysate

1 mg/mL

SLC30A8 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SLC30A8 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Two isoforms of SLC30A8 are known to exist; this antibody will detect both isoforms. This SLC30A8 antibody is predicted to not cross-react with other members of the SLC30 protein family.

SLC30A8

Solute carrier family 30 member 8

Homo sapiens

Chimienti F, Devergnas S, Favier A, et al. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004; 53:2330-7.

Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study indentifies novel risk loci for type 2 diabetes. Science 2007; 445:881-5.

Qu HQ, Grant SF, Bradfield JP, et al. Association analysis of type 2 diabetes Loci in type 1 diabetes. Diabetes 2008; 57:1983-6.

Egefjord L, Jensen JL, Bang-Berthelsen CH, et al. Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis? BMC Endocrine Disorders 2009; 9:7.

SLC30A8 Antibody: Solute carrier family 30 member 8, zinc transporter 8, ZNT8, Zn-T8

ELISA, WB, IHC-P, IF

64762489

Liquid