SLC36A2 Antilichaam

SLC36A2 is a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline (1,2) . Both SLC36A2 and its paralog SLC36A1 are expressed in neurons, but SLC36A2 localizes to the endoplasmic reticulum and recycling endosome, while SLC36A1 is expressed in the lysosome (2) . SLC36A2 is thought to contribute to neuronal transport and sequestration of amino acids such as glycine, alanine, and proline (2) . Mutations in this gene are associated with iminoglycinuria and hyperglycinuria (3) .

153201

Q495M3

NP_861441

Human

Unconjugated

Primary Antibodies

Homeostasis, Neuroscience

SLC36A2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1319 - Human Stomach Tissue Lysate

1 mg/mL

SLC36A2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SLC36A2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SLC36A2 antibody is human specific. SLC36A2 is predicted to not cross-react with other members of the SLC36 protein family.

SLC36A2

Solute carrier family 36 (proton/amino acid symporter), member 2

Homo sapiens

Boll M, Foltz M, Rubio-Aliaga I, et al. Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. J. Biol. Chem. 2002; 277:22966-73.

Rubio-Aliaga I, Boll M, Vogt Weisenhorn DM, et al. The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1. J. Biol. Chem. 2004; 279:2754-60.

Broer S, Bailey CG, Kowalczuk S, et al. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. J. Clin. Invest. 2008; 118:3881-92.

Solute carrier family 36 (proton/amino acid symporter) member 2, proton-coupled amino acid transporter 2, PAT2, TRAMD1

ELISA, WB

222418631

Liquid