SLC7A11 Antilichaam

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc (-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death.

23657

Q9UPY5

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human SLC7A11 (NP_055146.1) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Signal Transduction

Affinity purification

Mouse liver

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 37kDa

IgG

WB: 1:500 - 1:2000

SLC7A11

Mouse kidney

Rat liver

Solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

Homo sapiens

SLC7A11, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, CCBR1, xCT, cystine/glutamate transporter

WB

Liquid