SLCO1B1 Antilichaam

SLCO1B1 is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and may play an important role in the clearance of bile acids and organic anions from the liver (1,2) . It contains one Kazal-like domain and belongs to the organo-anion transporter family (2,3) . SLCO1B1 is highly expressed in liver and is localized to the basolateral hepatocyte membrane. It is responsible for the hepatic uptake of the liver-specific hydroxymethylglutaryl-CoA reductase inhibitor in mouse, rat and human (3,4) .

10599

Q9Y6L6

NP_006437

Human

Unconjugated

Primary Antibodies

Homeostasis

SLCO1B1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1304 - Human Liver Tissue Lysate

1 mg/mL

SLCO1B1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SLCO1B1 antibody can be stored at 4˚ C, stable for up to one year.

IgG

SLCO1B1 antibody is human specific. At least four isoforms of SLCO1B1 are known to exist. This antibody is predicted to not cross-react with other SLCO1B proteins.

SLCO1B1

Cat. No. 10-201 - Human Liver Tissue Slide

Solute carrier organic anion transporter family, member 1B1

Homo sapiens

Abe T, Kakyo M, Tokui T, et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J. Biol. Chem. 1999; 274:17159-63.

Konig J, Cui Y, Nies AT, et al. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am. J. Physiol. Gastrointest. Liver Physiol. 2000; 278:G156-64.

Michalski C, Cui Y, Nies AT, et al. A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter. J. Biol. Chem. 2002; 277:43058-63.

Yao J, Hong W, Huang J, et al. N-Glycosylation dictates proper processing of organic anion transporting polypeptide 1B1. PLoS One 2012; 7:e52563.

Solute carrier organic anion transporter family member 1B1, LST1, Solute carrier family 21 member 6, SLC21A6, Sodium-independent organic anion-transporting polypeptide 2, OATP1B1, OATP2, OATPC, Solute carrier family 21 member 6

ELISA, WB, ICC, IF

225543525

Liquid