SLIT2 Antilichaam

This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants.

9353

O94813

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 1330-1529 of human SLIT2 (NP_004778.1) .

Unconjugated

Primary Antibodies

Neuroscience, Signal Transduction

Affinity purification

293T

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 170kDa

IgG

WB: 1:200 - 1:2000

SLIT2

Slit homolog 2 (Drosophila)

Homo sapiens

SLIT2, slit homolog 2 (Drosophila), HGNC:11086, SLIL3, Slit-2

WB

Liquid