Slo1 (BK Channel, KCNMA1) Antibody, Kloon S22: APC

Slo1, also known as the BK (Big Potassium) channel or BKα, is a voltage- and calcium-activated potassium channel highly expressed in neurons and smooth muscle. It plays a critical role in regulating membrane excitability by facilitating the repolarization phase of action potentials and modulating neurotransmitter release. Slo1 channel activity is finely tuned by intracellular Ca²⁺ levels and membrane potential, and is further regulated by auxiliary KCNMB subunits. This dynamic regulation enables Slo1 to influence synaptic transmission, motor coordination, and responses to ethanol. Notably, Slo1 dysfunction has been implicated in a range of neurological and neuromuscular disorders, including epilepsy, ataxia, hypertension, and muscular dystrophy. Recent studies suggest that Slo1 may also contribute to neurodegenerative disease mechanisms by altering neuronal firing patterns and calcium homeostasis. Its interaction with dystrophin-related pathways further underscores its relevance in neuromuscular integrity. Given its broad physiological roles and disease associations, Slo1 is emerging as a promising target for therapeutic intervention and biomarker development in neurodegenerative research.

Rabbit Anti-Mouse Slo1 Recombinant Monoclonal IgG Kappa

Slo1, BKAlpha, maxi-K+ channel, Calcium-activated potassium channel subunit alpha-1, Calcium-activated potassium channel, Subfamily M subunit alpha-1, KCa1.1, K (VCA) alpha, BK channel, BKCA alpha, Maxi K channel, Slo-alpha, Slowpoke homolog, Kcnma1, Kcnma, Maxi Potassium channel alpha, KCMA1, Slo, BKCa, mSlo, MaxiK, mSlo1, 5730414M22Rik, BK, BKCA channel, K VCA, BKCA alpha subunit, BKTM, Drosophila slowpoke like, SAKCA

12352203

Non-hazardous

Non-hazardous

16531

Q08460

AAA39746.1

Fusion protein, AA #690-1196 (cytoplasmic C-terminus) of mouse Slo1. Epitope mapped to within AA #690-715 (PKLMRHDPLLIPGNDQIDNMDSNVKK) .

S22

APC

Widely expressed. Found in glandular tissues, smooth and skeletal muscles, and in neural tissues.

Recombinant Monoclonal

WB | IHC | ICC/IF

Cancer | Cell Signaling | Neuroscience | Ion Channels | Potassium Channels | Calcium-Activated Potassium Channels | Cardiovascular System

AmMagTM Ultra AT Protein A MagBeads

1 µg/ml was sufficient for detection of Slo1 on Rat Brain Membrane lysate.

1mg/ml

WB (1:1000), IHC (1:100), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.; optimal dilutions for assays should be determined by the user.

95.46mM Phosphate, 2.48mM MES and 2mM EDTA

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Blue Ice or 4ºC

Conjugated antibodies should be stored according to the product label

https://www.stressmarq.com/wp-content/uploads/Antibody-MSDS.pdf

Detects C-terminus of Slo1, epitope mapped to within AA #690-715 (PKLMRHDPLLIPGNDQIDNMDSNVKK) .

1. Yang, C.T., Zeng X.H., Xia X.M., and Lingle C.J. (2009) . Interactions between β Subunits of the KCNMB Family and Slo3: β4 Selectively Modulates Slo3 Expression and FunctionPloS One. 4 (7) : e6135. DOI: 10.1371/journal.pone.0006135 2. Latorre, R., & Brauchi, S. (2006) . Large conductance Ca2+-activated K+ (BK) channel: Activation by Ca2+ and voltage. Biological Research, 39 (3), 385-401. DOI: 10.4067/s0716-97602006000300003 3. Petkov G. V. (2014) . Central role of the BK channel in urinary bladder smooth muscle physiology and pathophysiology. American journal of physiology. Regulatory, integrative and comparative physiology, 307 (6), R571–R584. DOI: 10.1152/ajpregu.00142.2014 4. Pathak, D., Guan, D., & Foehring, R. C. (2016) . Roles of specific Kv channel types in repolarization of the action potential in genetically identified subclasses of pyramidal neurons in mouse neocortex. Journal of neurophysiology, 115 (5), 2317–2329. DOI: 10.1152/jn.01028.2015 5. Kim, H., Pierce-Shimomura, J. T., Oh, H. J., Johnson, B. E., Goodman, M. B., & McIntire, S. L. (2009) . The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans. PLoS genetics, 5 (12), e1000780. DOI: 10.1371/journal.pgen.1000785

Human | Mouse | Rat

Cell Membrane, Nucleus

IgG Kappa

Mouse