Smad3 (fosfo Ser425) Antilichaam

Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

4088

P84022

NP_001138574.1

Human, Mouse, Rat

Smad3 (Phospho-Ser425) antibody was raised against a peptide sequence around phosphorylation site of serine 425 (C-S-S-V-S (p) ) derived from Human Smad3.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

52 kDa

This antibody detects endogenous level of Smad3 only when phosphorylated at serine 425.

Immunohistochemistry: 1:50~1:100

SMAD3

SMAD family member 3

Homo sapiens

Shi W, et al. J Cell Sci. 2007 Apr 1;120 (Pt 7) : 1216-24Seong HA, et al. J Biol Chem. 2007 Apr 20;282 (16) : 12272-89Wordinger RJ, et al. Invest Ophthalmol Vis Sci. 2007 Mar;48 (3) : 1191-200LeClair RJ, et al. Circ Res. 2007 Mar 30;100 (6) : 826-33

LDS3, LDS1C, MADH3, JV15-2, HSPC193, HsT17436, PTP2C, SHPTP2, MAD-3, Mad3, Mothers against DPP homolog 3

IHC

223029440

Liquid