SMAD6 Antilichaam - N-terminalgebied: FITC (ARP32690_T100-FITC)

SMAD family member 6

AOVD2, MADH6, MADH7, HsT17432

4091

O43541

NP_005576

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD6

SMAD6 (mothers against decapentaplegic homolog 6) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD.

ITCH; SMURF2; BPIFA1; NEDD4L; WWP2; WWP1; USP15; USP11; PIGR; NASP; LYZ; KPNA2; CTBP2; CTBP1; UBC; ACVR1; UBE2O; BAMBI; STAMBP; ACTR1B; TGFBR1; MYD88; SMAD1; BMPR2; BMPR1B; BMPR1A; ACVR2B; ACVR1B; SMURF1; PELI1; CUL2; ELAVL1; SMAD5; RPS6KA5; TSC22D1; MAPK

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

IHC, WB

There is BioGPS gene expression data showing that SMAD6 is expressed in Jurkat

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 91%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

53kDa

Tsunobuchi, H., et al., (2004) Biophys. Res. Commun. 316 (3),712-719

Wet Ice

496

SMAD6

SMAD6

Rabbit

Mothers against decapentaplegic homolog 6

NM_005585

APRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKR