SMAD7 Antilichaam

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3) . Several transcript variants encoding different isoforms have been found for this gene.

4092

O15105

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMAD7 (NP_005895.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Signal Transduction

Affinity purification

Mouse kidney

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 46kDa

IgG

SMAD7

Mouse liver

Rat kidney

Rat liver

SMAD family member 7

Homo sapiens

SMAD7, CRCS3, MADH7, MADH8

WB, IF

Liquid