SMARCA4 Antilichaam, KO gevalideerd

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene.

6597

P51532

Human

A synthetic peptide corresponding to a sequence within amino acids 30-130 of human SMARCA4 (NP_003063.2) .

Unconjugated

Primary Antibodies

Antibody is Knockout validated.

Cancer, Neuroscience, Stem Cell

Affinity purification

OVCAR3

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 180kDa

IgG

SMARCA4

HeLa

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4

Homo sapiens

SMARCA4 Antibody: BRG1, SNF2, SWI2, MRD16, RTPS2, BAF190, SNF2L4, SNF2LB, hSNF2b, BAF190A, BRG1, SNF2B, Transcription activator BRG1, ATP-dependent helicase SMARCA4

WB, IHC, IF

Liquid