SMC1 (fosfo Ser957) Antilichaam

Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.

8243

Q14683

NP_006297.2

Human, Mouse

SMC1 (Phospho-Ser957) antibody was raised against a peptide sequence around phosphorylation site of serine 957 (G-S-S (p) -Q-G) derived from Human SMC1.

Unconjugated

Primary Antibodies

Phospho-Specific, Cell Cycle

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

145 kDa

This antibody detects endogenous level of SMC1 only when phosphorylated at serine 957.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

SMC1A

Structural maintenance of chromosomes 1A

Homo sapiens

Yang XM. et al. (2004) Mol Cell Biol. 24 (12) : 5290-5303. Kim ST. et al. (2002) Genes Dev. 16 (5) : 560-570. Revenkova E. et al. (2001) Mol Cell Biol. 21 (20) : 6984-6998

SMC1, SMCB, CDLS2, SB1.8, SMC1L1, DXS423E, SMC1alpha, APRF, SM1A, SMC1A, SMC1 alpha protein

WB, IHC

30581135

Liquid