SMC1 (SMC1A) Mouse Monoclonal Antibody [Kloon ID: LBI11E1]

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Carrier-free (BSA/glycerol-free) SMC1A mouse monoclonal antibody, clone LBI11E1

CDLS2; DXS423E; SB1.8; SMC1; SMC1alpha; SMC1L1; SMCB

Homo sapiens structural maintenance of chromosomes 1A (SMC1A), transcript variant 1, mRNA.

8243

Q14683

Unconjugated

Cell cycle, Oocyte meiosis

Cell cycle, Oocyte meiosis

WB 1:500~2000, IHC 1:1000

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

SMC1A

https://www.ncbi.nlm.nih.gov/gene/?term=8243

https://www.uniprot.org/uniprot/Q14683