SMURF2 Antilichaam

SMURF2 (SMAD ubiquitin regulatory factor 2) is a negative regulator of TGF-beta signaling (1) . SMURF1 and SMURF2 are members of HECT domain E3 ubiquitin ligase which are involved in the enzymatic reactions of the Ub conjugating pathway (1,2) . SMURF2 is widely expressed and was initially identified as an inhibitor of TGF-beta/BMP signaling by targeting R-Smads and TGF type I receptor for ubiquitination and degradation (3) . Studies have shown that SMURF2 functions as a tumor suppressor by maintaining genomic stability through targeting RNF20 (3) . SMURF2 associates constitutively with SMAD7 (4) .

64750

Q9HAU4

NP_073576

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Signal Transduction

SMURF2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1285 - C2C12 Cell Lysate

1 mg/mL

SMURF2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SMURF2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

SMURF2 antibody is human, mouse and rat reactive. SMURF2 is predicted to not cross-react with SMURF1.

SMURF2

SMAD specific E3 ubiquitin protein ligase 2

Homo sapiens

Huibregtse JM, Scheffner M, Beaudenon S, et al. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. USA 1995; 92:2563-7.

Hwang YS, Lee HS, Kamata T, et al. The Smurf ubiquitin ligases regulate tissue separation via antagonistic interactions with ephrinB1. Genes Dev. 2013; 27:491-503.

Lin X, Liang M, and Feng XH. Smurf2 is a ubiquitin E3 ligase mediating proteasomedependent degradation of Smad2 in transforming growth factor-beta signaling. J. Biol. Chem. 2000; 275:36818-22.

Kavsak P, Rasmussen RK, Causing CG, et al. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-beta receptor for degradation. Mol. Cell 2000; 6:1365-75.

SMURF2 Antibody: E3 ubiquitin-protein ligase SMURF2, SMAD ubiquitination regulatory factor 2, hSMURF2

ELISA, WB, IHC-P, IF

12232397

Liquid