SNAI1 (fosfo Ser246) Antilichaam

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA) -induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.

6615

O95863

NP_005976.2

Human, Mouse

SNAI1 (phospho Ser246) antibody was raised against a peptide sequence around phosphorylation site of Serine 246 (T-F-S (p) -R-M) derived from Human SNAI1.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

29 kDa

IgG

The antibody detects endogenous levels of SNAI1 only when phosphorylated at serine 246.

Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

SNAI1

Snail family zinc finger 1

Homo sapiens

Okubo T., Cancer Res. 61:1338-1346 (2001) .

Twigg S.R., Hum. Genet. 105:320-326 (1999) .

Paznekas W.A., Genomics 62:42-49 (1999) .

SNAH, SNAI, Sna, Snail

WB, IF

18765741

Liquid